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Nicole F. Steinmetz

University of California San Diego

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AUG 10, 2026 · JOURNAL ARTICLE

DifferentialChemoselectivity of Homobifunctionaland Monofunctional Maleimide Reagents for Bioconjugation

Bioconjugate Chemistry

An exploratory chemical characterization study demonstrating differential reactivity patterns of maleimide reagents; raises mechanistic questions about linker valency but does not test clinical or therapeutic outcomes.

Hypothesis-GeneratingNicole F. Steinmetz Sean K. Hsu

Study details

DesignIn vitro chemical characterization study

InterventionBivalent maleimide linker (mal-PEG11-mal) a…

ComparatorComparison of mono- versus bivalent maleimi…

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