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Kiyomitsu Kuninaga

Kyoto University

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AUG 18, 2026 · JOURNAL ARTICLE

Clinical significance of inhaled COPD therapy in advanced or recurrent non-small cell lung cancer in the immune checkpoint inhibitor era: a multicenter retrospective cohort study

Scientific Reports

Retrospective cohort study showing that inhaled COPD therapy associates with longer overall survival in advanced NSCLC, but the effect is confounded by ICI use and disappears in ICI-treated patients, confirming that ICI is the dominant prognostic factor.

Important Confirmatory EvidenceHitomi Ajimizu Chronic Obstructive Pulmonary Disease (COPD) Research Lung Cancer Diagnosis and Treatment

Reported

Sample size (COPD-treated)144

Sample size (COPD-untreated)311

Total sample size455

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