Disease

Major Depressive Episode

3 developments in the corpus

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Latest

Everything in the corpus, newest first.

SEP 9, 2026 · PHASE 1/2 TRIAL

Personalized Ultrasonic Brain Stimulation for Depression

ClinicalTrials.gov

Phase 1/2 uncontrolled feasibility study of a novel device with surrogate endpoints (MRI activation, mood scales); no results reported in this registry record.

PreliminaryUniversity of Utah NCT05301036 Diadem prototype

Reported

Sample size22

PhasePhase 1/2

Primary outcome measure 1Target engagement: MRI quantification of br…

SEP 8, 2026 · PHASE 1/2 TRIAL

Personalized Ultrasonic Brain Stimulation for Depression (R61)

ClinicalTrials.gov

Phase 1/2 device feasibility study with no reported results; enrollment and outcome measures described but efficacy data not yet available in this registry record.

PreliminaryTreatment Resistant Major Depressive Disorder Brian Mickey Depression Major Depressive Disorder

Reported

Planned enrollment30

Study phasePhase 1/Phase 2

Primary outcome measure 1Modulation of SCC activity during SCC stimu…

AUG 12, 2026 · OBSERVATIONAL STUDY

Cohort of Patients Suffering From Major Depressive Episode With Evaluation of Sleep, Circadian Rhythms and Psychiatric Disorders

ClinicalTrials.gov

This is an ongoing observational cohort registry record with no reported results; it describes a planned study designed to identify biomarkers in depression via sleep and circadian measures.

PreliminaryNCT05866991 Major Depressive Episode Assistance Publique - Hôpitaux de Paris

Reported

Planned enrollment1000

Primary outcome measureamount of REM sleep, at inclusion

Study typeObservational