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AUG 15, 2026 · JOURNAL ARTICLE

Prognostic value of tissue-based DNA methylation biomarkers in non-small cell lung cancer: a systematic review

BMC Cancer

Systematic review of 20 studies confirming that tissue-based DNA methylation is frequently associated with worse survival in NSCLC, but methodological heterogeneity and lack of meta-analysis prevent definitive clinical recommendations.

Important Confirmatory EvidenceHistone Deacetylase Inhibitors Research Lung Cancer Treatments and Mutations Epigenetics and DNA Methylation

Reported

Proportion of adverse associations77.5% (31/40)

miR-34b/c hazard ratio3.34

EGLN2 hazard ratio1.71

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