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Lu Yang

First Affiliated Hospital Zhejiang University

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AUG 11, 2026 · JOURNAL ARTICLE

Tuberculous Arthritis Diagnosed by Metagenomic Sequencing after Negative Microbiology Studies and a 4-Year Delay

American Journal of Tropical Medicine and Hygiene

A single case report describing successful diagnostic use of metagenomic sequencing in culture-negative tuberculous arthritis, with clinical resolution after treatment, but lacking comparative data, control arm, or prospective validation.

PreliminaryJin Rilong Li Xiang Infectious Diseases and Tuberculosis

Reported

Patient age70 years

Duration of knee symptoms before…2 years

Time from presentation to mNGS di…nearly 2 years

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