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Xiaoqiao Cui

Harbin Medical University

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SEP 8, 2026 · JOURNAL ARTICLE

Metabolic predictors of response to immunotherapy in locally advanced or metastatic esophageal cancer: unveiling the obesity paradox

Scientific Reports

A sound retrospective cohort study with internal and external validation showing that high BMI predicts superior immunotherapy outcomes in esophageal cancer, but limited by observational design, modest sample size, and reliance on surrogate endpoints rather than hard clinical outcomes.

PromisingGangcai Zhu Jiaqi Tan Cancer Risks and Factors

Reported

Sample size286

Study centers2

Nomogram validation timepoints24- and 36-month overall survival

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