Disease
3 developments in the corpus
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AUG 24, 2026 · JOURNAL ARTICLE
Frontiers in Bioengineering and Biotechnology
A comprehensive review synthesizing current state, clinical milestones, and translational barriers in gene therapy for genodermatoses, offering expert perspective on therapeutic landscape and implementation challenges.
AUG 21, 2026 · JOURNAL ARTICLE
Frontiers in Cell and Developmental Biology
An in vitro hiPSC-derived keratinocyte model establishing mechanistic links between KRT5 variants and inflammatory pathways, with a proposed but unvalidated therapeutic target in a disease without prior direct clinical evidence.
AUG 17, 2026 · JOURNAL ARTICLE
American Journal of Physiology-cell Physiology
In vitro mechanistic study in immortalized keratinocytes using CRISPR knockouts, demonstrating pathway defects and proof-of-concept rescue; lacks in vivo validation or clinical outcome data required for stronger evidence.