AUG 21, 2026 · JOURNAL ARTICLE
An isogenic hiPSC-derived keratinocyte model reveals CXCL10/CXCL11 inflammatory dysregulation in epidermolysis bullosa simplex
Frontiers in Cell and Developmental Biology
An in vitro hiPSC-derived keratinocyte model establishing mechanistic links between KRT5 variants and inflammatory pathways, with a proposed but unvalidated therapeutic target in a disease without prior direct clinical evidence.
Study details
DesignIn vitro mechanistic study with isogenic CR…
InterventionhiPSC-derived keratinocytes carrying KRT5 v…
ComparatorGenetically corrected isogenic keratinocyte…