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Indian Journal of Physiotherapy and Occupational Therapy - an International Journal
A small uncontrolled case series (n=5) with a two-week intervention and no comparator, reporting surrogate endpoints and quality-of-life measures without a control group or long-term follow-up.
Single-center retrospective analysis of 86 patients with exploratory, hypothesis-generating associations between genomic alterations and clinical outcomes; the authors explicitly state prospective validation in larger cohorts is necessary before clinical application.
Large national cohort study with hard clinical outcome (overall survival) showing inferior outcomes with dose de-escalation, aligning with recent randomized evidence and supporting current standard-of-care dosing.
Rigorous population-based retrospective cohort study with multivariable adjustment comparing four treatment strategies in localized oral cavity cancer, demonstrating significantly improved survival with elective neck dissection versus omission or radiotherapy alone.
Single-institution prospective cohort with uniform treatment identifying prognostic factors for disease-free survival in oral cavity cancer, but lacks a comparator group and generalizability is limited to one centre.
A small randomized controlled trial with a statistically significant primary endpoint (p=0.0008) and reported improvements in swallowing, voice, and GRBAS scores, but limited by modest sample size, lack of reported effect sizes, and insufficient detail on methods and follow-up.
Post hoc analysis of a phase II trial with small sample (n=29) and surrogate/exploratory endpoints; findings are hypothesis-generating and require validation in larger populations.
Single-center cohort of six patients from a prematurely terminated phase 2 trial with descriptive analysis only; feasibility and immune remodeling demonstrated but efficacy and safety conclusions explicitly limited by sample size and trial discontinuation.