AUG 14, 2026 · JOURNAL ARTICLE
Metformin modulates the phenotypes of tumor-associated macrophages in glioblastoma in a context-dependent manner by promoting the homeostasis of macrophages
Frontiers in Oncology
Preclinical syngeneic mouse model study with mechanistic in vitro work showing metformin + radiotherapy prolongs survival and reduces tumor burden through immune reprogramming, but lacks human data and hard clinical endpoints.
Reported
Survival prolongationsignificantly prolonged
Tumor burdenreduced
CD8+/Treg ratioelevated