Nuclear Receptors and Signaling

SEP 10, 2026 · JOURNAL ARTICLE

Macrophage migration inhibitory factor is a potential therapeutic target for cisplatin induced peripheral neuropathy in breast cancer

Neuro-oncology Advances

Mechanistic preclinical study in mouse models proposing MIF as a therapeutic target; lacks clinical validation, hard endpoints, or translation to patient benefit.

SEP 5, 2026 · JOURNAL ARTICLE

PRMT7 restricts CD8+ T cells expansion via the NF-ΚB pathway

Nature Communications

A mechanistically sound study combining genetic and pharmacological approaches in mouse and human models, demonstrating PRMT7 inhibition enhances CD8+ T cell function, but limited by single tumor model and lack of phase-controlled clinical trial.