He Zhu

SEP 9, 2026 · JOURNAL ARTICLE

Integrative multi-omics profiling of insomnia-related molecular features reveals microbiome, immune, and therapy-relevant heterogeneity in colorectal cancer

Microbiology Spectrum

This is an exploratory multi-omics association study using unsupervised clustering to identify molecular subtypes linked to insomnia features in CRC; it raises mechanistic questions and generates a risk score but lacks prospective validation, a comparator arm, or hard clinical outcome data to support causal inference or clinical action.