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Jiayi Wang

State Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.

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SEP 4, 2026 · JOURNAL ARTICLE

A conserved E1 stem motif functions as a virulence switch in the emerging Getah virus.

Virulence

Mechanistic study using reverse genetics in cell culture and animal models to identify a virulence determinant; lacks clinical outcomes or efficacy data needed to guide vaccine development or clinical practice.

Hypothesis-GeneratingAlphavirus Infections Chunpeng Ma Xinna Ge

Reported

Primary observation9-nucleotide deletion in E1 glycoprotein st…

Motif conservationNQVF highly conserved among GETV strains an…

Lethality in neonatal micecompletely abrogated by E1 deletion mutant

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