Disease

Alphavirus Infections

2 developments in the corpus

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SEP 4, 2026 · JOURNAL ARTICLE

A conserved E1 stem motif functions as a virulence switch in the emerging Getah virus.

Virulence

Mechanistic study using reverse genetics in cell culture and animal models to identify a virulence determinant; lacks clinical outcomes or efficacy data needed to guide vaccine development or clinical practice.

Hypothesis-GeneratingAlphavirus Infections Chunpeng Ma Xinna Ge

Reported

Primary observation9-nucleotide deletion in E1 glycoprotein st…

Motif conservationNQVF highly conserved among GETV strains an…

Lethality in neonatal micecompletely abrogated by E1 deletion mutant

JUN 18, 2026 · JOURNAL ARTICLE

The 3'Untranslated region is a critical determinant of Getah virus replication, pathogenesis, and vector competence.

Virulence

Reverse genetics study in cell culture and animal models establishing the GETV 3'UTR's role in replication and pathogenesis, but lacks clinical translation, human data, and comparative efficacy evidence needed for practice-changing or strong designation.

PreliminaryAlphavirus Infections Zuzhang Wei Muyang Liu

Reported

Maximum tolerated consecutive del…310 nucleotides

Mortality in rGETV-KO310-infected…0

Clinical outcome in rGETV-KO310-i…transient morbidity only