Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
2 developments in the corpus
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This is a proof-of-concept study describing development and optimization of a new genetic tool in a bacterial model system, with successful gene knockouts demonstrated but no clinical or translational validation beyond candidate strain construction.
This is a preclinical study combining transcriptomic analysis, virtual screening, and chemical synthesis followed by testing in animal models, raising mechanistic questions about AKR1B10 and COF scaffolds rather than establishing clinical efficacy.