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Multimodal Biomarkers

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JUN 18, 2026 · JOURNAL ARTICLE

Decreased awareness of cognitive decline is associated with multimodal Alzheimer's disease biomarkers in cognitively unimpaired individuals.

Neurobiology of Aging

A single-centre prospective cohort study with well-defined neuropsychological criteria identifying a discrete clinical phenotype (decreased awareness of cognitive decline) associated with multimodal AD biomarkers in cognitively unimpaired individuals; promising but requires replication and validation in independent populations.

PromisingMahnaz Shekari Biomarkers Alzheimer Disease

Reported

Sample size350

Memory decline prevalence61/350 (17%)

Decreased ACD among those with me…25/61 (41%)

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