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Cross-sectional study demonstrating clear associations between CMI and hepatic enzymes and metabolic markers in overweight/obese adults, but limited by observational design and inability to establish causation.
Cross-sectional study in 304 obese adults showing LAP correlates with metabolic and hematological markers with good discriminatory performance (AUC 0.833) for metabolic syndrome, but lacks prospective design and causal evidence needed to establish clinical utility.