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Martina Contu

Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.

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AUG 15, 2026 · JOURNAL ARTICLE

Comparing trajectories of cognitive functioning in treatment-resistant and non-resistant depression: a multicentre linear mixed-effects analysis.

Journal of Affective Disorders

A well-designed observational cohort study with adequate sample size and rigorous statistical method (linear mixed modelling) reporting clear differences in cognitive trajectories between TRD and non-TRD patients, but limited to 12 weeks and requiring confirmation in longer-term, interventional designs.

PromisingTreatment Resistant Depression Viktor T H Wahner Inga Stonner

Reported

Sample size320

TRD subgroup118

Non-TRD subgroup202

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