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Sivanandhan Rajendiran

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AUG 5, 2026 · JOURNAL ARTICLE

Decoding the Genetic Basis of Alzheimer's Disease: A Comprehensive Review of Key Causal and Risk Genes, Pathological Mechanisms, Convergent Pathways, and Emerging Therapeutic Targets

Middle East Research Journal of Medical Sciences

This is a comprehensive narrative review synthesizing current knowledge of AD genetics, pathways, and therapeutic targets rather than presenting original research evidence or clinical trial data.

Expert GuidanceSharan Kumar Alzheimer's Disease Research and Treatments Sivakumar Subramaniyan

Reported

Proportion of dementia cases attr…60–70%

Current number of individuals aff…55 million

Projected number of affected indi…139 million

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