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Fernando G Zampieri

Department of Critical Care Medicine, University of Alberta, Canada. Electronic address: fzampier@ualberta.ca.

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JUL 31, 2026 · JOURNAL ARTICLE

Safety and outcomes of dapagliflozin initiation in critically ill patients with acute kidney injury: A post-hoc analysis of the defender trial.

Journal of Critical Care

A post-hoc analysis from a controlled trial showing no safety signal for dapagliflozin in critically ill AKI patients, with near-neutral effects and physiological stability, but underpowered to detect clinically meaningful benefit or harm.

PromisingCaio A M Tavares Álvaro Rea-Neto Renal Replacement Therapy

Reported

28-day mortality (dapagliflozin v…38% vs 40%

Kidney replacement therapy (dapag…12% vs 18%

Composite death/KRT (dapagliflozi…41% vs 42%

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