AUG 18, 2026 · JOURNAL ARTICLE
Select intratumoral riboflavin-auxotrophic Enterococcus species enhance cell surface MR1 expression and MAIT TCR activation in lung cancer
Proceedings of the National Academy of Sciences
Mechanistic study in vitro and from sequencing datasets showing bacterial modulation of MR1 expression and MAIT activation, raising a question about whether this influences checkpoint blockade response rather than demonstrating a clinical effect.
Study details
DesignObservational single-cell RNA and TCR seque…
InterventionIn vitro exposure of tumor cells and antige…
ComparatorCells not exposed to Enterococcus or 5-OP-R…