AUG 11, 2026 · JOURNAL ARTICLE
Association of hypertension and diabetes with opioid initiation and progression to long-term use after osteoarthritis diagnosis: A population-based register cohort study in Sweden.
Osteoarthritis and Cartilage Open
A large population-based register cohort study with rigorous design, clear relative risk estimates with confidence intervals for both primary outcomes, and adequate statistical adjustment, though observational design limits causal inference.
Reported
Sample size48778
Hypertension alone—first opioid d…1.16
Hypertension alone—first opioid d…1.12; 1.20