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Observational cohort study with hard clinical outcomes (mortality) in a large, nationally representative US sample, but dependent on cross-sectional exposure measurement and unable to establish causation; requires prospective validation.
Single-centre retrospective study with moderate diagnostic accuracy (AUC ~0.61) on a surrogate imaging endpoint; model performance is modest and requires external validation before clinical use.
This is an early-stage preclinical study demonstrating a novel nanoplatform in a mouse sepsis model with in vitro validation, lacking human clinical data and requiring confirmation in larger studies before clinical translation.