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Pei Ma

Jiangsu Province Hospital

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AUG 10, 2026 · JOURNAL ARTICLE

A predictive model for immunotherapy efficacy in cancer based on dynamic changes of CD8+ T cells: a pan-cancer retrospective study

Frontiers in Immunology

Retrospective single-cohort study with internal validation showing CD8+ T cell dynamics predict immunotherapy outcomes via a novel risk model, but lacks external validation and prospective design needed to change practice.

PromisingYongqian Shu Immunotherapy and Immune Responses Jun Zhang

Reported

Hazard ratio for decreased CD8+ T…0.2308

95% CI for CD8+ T cell HR0.0875–0.5636

Time-dependent AUC at 2.5 months0.727

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