AUG 8, 2026 · JOURNAL ARTICLE
Loss of Farnesoid X Receptor promotes colorectal liver metastasis via the GutFXR–FGF15–PPARγ–VEGFα–MDSC axis
Molecular Medicine
Preclinical mechanistic study in mouse models identifying a signaling axis and proposing a therapeutic target, without human efficacy data or clinical validation.
Study details
DesignPreclinical mechanistic study in mouse mode…
InterventionFXR knockout or Ursodeoxycholic Acid (UDCA)…
ComparatorImplicitly wild-type or untreated controls,…