SEP 1, 2026 · JOURNAL ARTICLE
Beyond Efficacy Signals: Regulatory, Methodological, and Translational Challenges in Clinical Research on Ketamine and Psilocybin in Psychiatry
Psychiatry International
A structured narrative review synthesizing methodological and regulatory challenges across ketamine and psilocybin trials, identifying systemic weaknesses in trial design and implementation readiness rather than reporting a primary efficacy result.
Reported
Literature search scopePubMed/MEDLINE through 21 July 2026
Empirical foundation studies6