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May Shuen Tang

National University of Singapore

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SEP 7, 2026 · JOURNAL ARTICLE

Elevated liver enzymes is not an impediment to allopurinol dose escalation: an observational cohort study

Arthritis Care & Research

A prospective observational cohort showing that mild transaminase elevation during allopurinol therapy does not worsen and does not require dose interruption; sound method but limited by single-centre design, lack of control group, and modest sample size.

PromisingQai Ven Yap Amelia Santosa Liver Disease Diagnosis and Treatment

Reported

Sample size150

Mean age (years)56.6

Median follow-up (weeks)33.5

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