AUG 11, 2026 · JOURNAL ARTICLE
T cell receptor repertoire dynamics and newly identified functional regulators of autologous tumor-infiltrating lymphocyte therapy in advanced solid tumors
Journal of Translational Medicine
Phase 1 investigator-initiated trial in 12 patients with heterogeneous solid tumors, showing feasibility and a 33.3% response rate, but underpowered for efficacy claims and mechanistic findings rely on uncontrolled in vitro and in vivo knockout experiments.
Reported
Objective response rate33.3% (4/12)
Complete response1/12
Partial response3/12