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Dimitrios Kalampokis

National and Kapodistrian University of Athens

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AUG 19, 2026 · JOURNAL ARTICLE

Models of depression for preclinical drug discovery and development: an update of the literature

Expert Opinion on Drug Discovery

A narrative review synthesizing preclinical animal model literature to identify biological mechanisms of depression and propose methodological improvements for drug discovery; raises questions about model validity and translational strategy rather than testing a clinical hypothesis.

Hypothesis-GeneratingPavlina Pavlidi Tryptophan and Brain Disorders Ioannis Sotiropoulos

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DesignNarrative literature review

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