SEP 10, 2026 · JOURNAL ARTICLE
Interpretable four-class machine learning prediction of initial I-131 therapy responses in differentiated thyroid cancer
Annals of Medicine
Single-center machine learning model with reasonable test-set performance (AUC 0.894) and independent temporal validation, but surrogate endpoints (biochemical markers and imaging classification) rather than hard clinical outcomes, and no comparison to standard risk stratification.
Reported
AUC (test cohort)0.894
95% CI AUC (test cohort)0.842–0.901
AUC (validation cohort)0.885