Disease

Staphylococcal Infections

2 developments in the corpus

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SEP 4, 2026 · JOURNAL ARTICLE

Experimental evolution of phage K enhances antibacterial activity against USA300 MRSA in lung infection models.

Emerging Microbes & Infections

Experimental evolution study using in vitro and ex vivo models to characterize an adapted phage variant; no animal infection efficacy data, clinical outcomes, or in vivo proof of concept reported.

Hypothesis-GeneratingFranziska Hornung Disease Models, Animal Swanti Schapp

Study details

DesignExperimental evolution study with in vitro…

InterventionEvolved phage KJ25 (derivative of phage K w…

ComparatorWild-type phage K

AUG 30, 2026 · JOURNAL ARTICLE

Cryptotanshinone inhibits Staphylococcus aureus NdhC via uncompetitive inhibition: Collateral sensitivity in respiratory-deficient SCVs.

Virulence

This is a mechanistic study using in vitro enzymatic assays, molecular docking, and site-directed mutagenesis to characterize cryptotanshinone's inhibition of bacterial NADH dehydrogenase; it raises questions about therapeutic potential rather than demonstrating clinical efficacy.

Hypothesis-GeneratingMing-Yu Huang Si-Yi Zhong Zheng-Cheng Yang

Reported

Fold increase in bacterial sensit…2-fold