SEP 1, 2026 · JOURNAL ARTICLE
587. Female-specific role of interleukin 6 and C-reactive protein in individuals with major depressive disorder and comorbid obesity
The International Journal of Neuropsychopharmacology
A sound cross-sectional study with pre-specified biomarker hypotheses and ROC analysis showing female-specific IL-6 and CRP associations with MDD in obesity, but limited by small sample size, single setting, and lack of longitudinal or independent validation.
Reported
Sample size85
MDD cases (female %)41 (63%)
Controls (female %)44 (57%)