SEP 8, 2026 · JOURNAL ARTICLE
Dapagliflozin reduces ventricular arrhythmogenesis and improves epicardial fat remodeling in a rat model of cardiometabolic HFpEF, associated with SIRT1–HIF1α-related biomarker changes
Scientific Reports
Animal model study with mechanistic findings on arrhythmia reduction; lacks human validation and hard clinical outcomes needed for stronger evidence grading.
Reported
Action potential duration paramet…APD 70
Primary mechanistic findingReduced VA inducibility and episode frequen…