JUL 31, 2026 · JOURNAL ARTICLE
Enhanced replication and immunogenicity of a genome-modified non-replicating vaccinia virus Tiantan strain for robust low-dose protection in mice
Journal of Virology
First-in-kind preclinical study in mice demonstrating proof-of-concept for an engineered vaccine candidate; lacks human data, comparative efficacy trials, and independent replication required to guide clinical practice.
Reported
Viral yield increase in MRC-5 cel…more than 680-fold
Pathogenicity reduction versus VTTmore than 10-fold decrease
Protection against lethal challen…100%