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Véronique N. Lafleur

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AUG 11, 2026 · JOURNAL ARTICLE

Hypoxia increases the activity of oncolytic adenoviruses through HIF-2α-stimulated E1A expression

Signal Transduction and Targeted Therapy

Mechanistic in vitro study demonstrating a novel biological principle (HIF-2α-driven E1A upregulation under hypoxia) without clinical outcomes, efficacy data, or in vivo therapeutic validation.

Hypothesis-GeneratingKerry Fisher Véronique N. Lafleur Leonard W. Seymour

Reported

E1A upregulation fold-change unde…17-fold

Time to E1A upregulation2 h

Number of adenovirus genotypes wi…59

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