SEP 8, 2026 · PREPRINT
Leveraging Cardiac Imaging to Improve ECG-Based Detection of Chagas Disease in Resource-Constrained Settings
arXiv
A machine learning method development study using pre-trained representations from unaffected populations (UK Biobank) to detect Chagas disease in external datasets; shows promising cross-validation and challenge performance but lacks prospective clinical validation, independent test cohort assessment, and clinical outcome data.
Reported
AUROC (aligned model, CODE-15% an…0.851
AUROC (unaligned baseline)0.827
Top 5% sensitivity (aligned model)0.427