AUG 18, 2026 · JOURNAL ARTICLE
Anticancer effects of an XPO1 inhibitor (selinexor) with sotorasib following omeprazole preconditioning in KRAS G12C-mutant non-small cell lung cancer cells in vitro and in a mouse tumor xenograft
Neoplasia
Early-phase in vitro and xenograft study showing proof-of-concept for a three-drug combination in KRAS G12C NSCLC cells; mechanistic finding without human clinical data or toxicology beyond weight observation.
Reported
Primary findingalmost completely suppressed colony formati…
XPO1 expression suppressioncompletely suppressed with three-drug combi…
Xenograft tumor growth inhibitionsignificantly inhibited