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Jingfang Zhao

Fudan University Shanghai Cancer Center

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AUG 13, 2026 · JOURNAL ARTICLE

Integrating a Ripple Filter into Pencil Beam Scanning Proton Therapy for Breast Cancer: from Dosimetric Feasibility to Acute Toxicity Assessment

BMC Cancer

A two-phase feasibility and safety study combining dosimetric planning with retrospective clinical validation in a single institution, showing efficiency gain and acceptable acute toxicity, but limited by retrospective design, modest sample size, and surrogate endpoints.

PromisingWei Sun Jingfang Zhao Qing Zhang

Reported

Mean ipsilateral lung dose increa…0.13 Gy(RBE)

95% CI, mean ipsilateral lung dos…0.08–0.28 Gy(RBE)

Mean heart dose increase (BCS)0.04 Gy(RBE)

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