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Steven R. Smith

Johns Hopkins University

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AUG 10, 2026 · JOURNAL ARTICLE

Impaired adipogenesis and lipid storage capacity in subcutaneous adipose tissue of patients with PMOS

Jci Insight

A mechanistically detailed transcriptomic study in a modest patient cohort identifying a potential pathway (SLIT2/ROBO signaling) that impairs adipogenesis in PCOS, supported by targeted cell culture validation but requiring confirmation in larger cohorts and functional studies.

PromisingKatie L. Whytock Cardiovascular Disease and Adiposity Timothy F. Osborne

Reported

PCOS cases enrolled15

Healthy BMI-matched controls17

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