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Michele Karolak

Middle East Institute

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SEP 8, 2026 · JOURNAL ARTICLE

Exosome trafficking is a key regulator of adipocyte thermogenesis

Proceedings of the National Academy of Sciences

Mechanistic study identifying exosome trafficking as a regulator of adipocyte thermogenesis in cell and mouse models, without clinical outcomes or human efficacy data to support therapeutic application.

Hypothesis-GeneratingCardiovascular Disease and Adiposity Aaron C. Brown Summer Pray

Study details

DesignMechanistic cell-based and mouse model expe…

InterventionGenetic deletion or pharmacological disrupt…

ComparatorWild-type controls or untreated adipocytes;…

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