AUG 18, 2026 · JOURNAL ARTICLE
SLPI is associated with AR-regulated epithelial adaptation and enzalutamide sensitivity in castration-resistant prostate cancer
Frontiers in Pharmacology
Mechanistic study combining computational analysis of public single-cell data with in vitro cell-line models to propose SLPI as a putative response factor; lacks clinical validation, in vivo evidence, and the authors explicitly state further validation is required.
Reported
Cell-line models studied22Rv1 and C4-2
Normal prostate cell line compara…RWPE-1
Public single-cell RNA-seq datase…GSE274229