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Dana C. Borcherding

Washington University in St. Louis

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AUG 11, 2026 · JOURNAL ARTICLE

Combined FAK and MEK inhibition suppresses chromosome 8 gain malignant peripheral nerve sheath tumors

Journal of Clinical Investigation

Mechanistic study with in vitro and PDX model evidence supporting a rational drug combination in a rare aggressive tumor, but lacks clinical trial data and human efficacy.

PromisingAngela C. Hirbe Liuzhan Yang Dana C. Borcherding

Reported

Essential genes on chr8 identifie…58

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