AUG 11, 2026 · JOURNAL ARTICLE
FAP-Inhibitor Homodimers with Engineered Linker-SpacerUnits: Toward Optimized Radiopharmaceuticals
Acs Omega
This is preclinical chemical and radiochemical characterization of novel compounds with in vitro binding and cell studies, lacking in vivo efficacy data or clinical translation to support therapeutic claims.
Reported
FAP affinity (Kd)1.1–1.2 nM
Cell internalization at 30 minutesup to 95%
Radiochemical purityhigh to quantitative