JUL 28, 2026 · JOURNAL ARTICLE
T cell dysfunction during Staphylococcus aureus osteomyelitis in humanized mice 2257659
The Journal of Immunology
A mechanistic study in a humanized mouse model with exploratory single-cell RNA sequencing and flow cytometry findings; the human serum correlation is observational and does not establish causality or clinical utility.
Reported
Animal age and sexFemale, 20-24 weeks old
Time to analysis post-infectionFourteen days
Immune checkpoint markers elevatedLAG-3, PD-1, TIM-3