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Andrea de Bartolomeis

Section of Psychiatry Department of Neuroscience, Reproductive Sciences, and Dentistry, University School of Medicine Federico II, Naples, Italy; Section of Psychiatry, Laboratory of Translational and Molecular Psychiatry, Unit of Treatment

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AUG 10, 2026 · JOURNAL ARTICLE

Prevalence and outcomes of real-world bipolar depression patients underrepresented in guideline RCTs.

Journal of Affective Disorders

Cross-sectional observational study of a single outpatient cohort using a surrogate measure (patient-perceived improvement) with no randomization or control group, raising questions about real-world treatment outcomes but not providing confirmatory evidence.

PreliminaryMichele Fornaro Bipolar Disorder Erica Luce Zeoli

Reported

RCT-eligible patients53/122 (43.4%)

Odds ratio (perceived improvement…9.83

95% CI (main OR)4.17-23.18

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