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Researcher

Mingguang Zhang

Chinese Academy of Medical Sciences & Peking Union Medical College

1 development in the corpus

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SEP 9, 2026 · JOURNAL ARTICLE

UQCRC2 lactylation-mediated mitophagy orchestrates colorectal cancer cell metabolism to establish a drug-tolerant state during chemotherapy

Molecular Cancer

Mechanistic study in cell and animal models identifying a pathway linking lactylation to drug tolerance, with clinical associations but no prospective clinical trial or intervention outcome data.

Hypothesis-GeneratingShuo Liang Cancer Cells and Metastasis Xiang Zhao

Reported

Clinical outcome correlationLow tumor UQCRC2-K430la associated with poo…

CTC biomarker associationIncreased SIRT1 or decreased UQCRC2-K430la…

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