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Ban Wreikat

Department of Anatomy, Physiology and Biochemistry, Faculty of Medicine, The Hashemite University, Zarqa, Jordan.

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JUN 3, 2026 · JOURNAL ARTICLE

Leucine-rich repeat kinase 2 (LRRK2): balancing cellular homeostasis and Parkinson's disease (PD) pathogenesis.

Annals of Medicine

A comprehensive narrative review synthesizing current understanding of LRRK2 biology and PD pathogenesis without primary empirical data or meta-analysis, providing mechanistic context for clinicians and researchers rather than practice-changing evidence.

Expert GuidanceTherapeutic Development Wasan Sameer Ban Wreikat

Reported

PD prevalence in population >60 y…1–2%

PD prevalence in population >85 y…4%

Global PD cases in 2016>6 million

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