AUG 12, 2026 · JOURNAL ARTICLE
The chromosomal instability associated gene C2orf76 exerts dual roles in colorectal cancer through pyroptosis and chemotherapy response
Frontiers in Oncology
Mechanistic cell-line study characterizing gene function through knockdown, overexpression, and rescue; no clinical outcomes or human validation; raises questions about C2orf76's dual roles rather than answering them in a patient context.
Reported
Study designKnockout (KO), overexpression (OE), and res…
Molecular assaysRNA-seq, RT-qPCR, Western blotting, GSDME c…