AUG 18, 2026 · JOURNAL ARTICLE
Evaluation of the concordance of two immunohistochemical antibodies (SP218 and MXR060) in detecting PTEN protein expression in breast cancer
Diagnostic Pathology
Well-designed single-center concordance study with clear methodology and strong statistical agreement (κ=0.98) that validates interchangeability of two antibodies in routine practice, but does not establish new clinical utility or change diagnostic approach.
Reported
Overall concordance rate99.3% (149/150)
Cohen's kappa (antibody concordan…0.98
Positive concordance rate97.1%