JUL 30, 2026 · JOURNAL ARTICLE
Antidepressant-like effects of valproic acid in rodents go back to the 1980s: a comment to enrich the reviewed evidence by Goudarzi et al. (2026) "Valproic acid effects on stress-induced depression-like behavior in rodent models: a systematic review and meta-analysis".
Stress
Historical commentary confirming antidepressant-like effects of valproic acid in rodent models first demonstrated in the 1980s, supporting recent meta-analytic findings but not providing new primary evidence.
Reported
Meta-analysis studies included19
Meta-analysis publication year ra…2007 to 2024
First historical demonstration of…1988